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KMID : 1007320160220030174
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Journal of the Korean Society of Menopause
2016 Volume.22 No. 3 p.174 ~ p.179
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Raloxifene Administration in Women Treated with Long Term Gonadotropin-releasing Hormone Agonist for Severe Endometriosis: Effects on Bone Mineral Density
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Choi Young-Hwa
Um Mi-Jung
Kim Suk-Jin
Kim Soo-Ah
Jung Hyuk
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Abstract
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Objectives: To evaluate the efficacy of raloxifene in preventing bone loss associated with long term gonadotropin-releasing hormone agonist (GnRH-a) administration.
Methods: Twenty-two premenopausal women with severe endometriosis were treated with leuprolide acetate depot at a dosage of 3.75 mg/4 weeks, for 48 weeks. Bone mineral density (BMD) was evaluated at admission, and after 12 treatment cycles.
Results: At cycle 12 of GnRH-a plus raloxifene treatment, lumbar spine, trochanter femoral neck, and Ward’s BMD differed from before the treatment. A year after treatment, the lumbar spine and trochanter decreased slightly, but were not significantly different.
Conclusions: Our study shows that the administration of GnRH-a plus raloxifene in pre-menopausal women with severe endometriosis, is an effective long-term treatment to prevent bone loss.
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KEYWORD
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Bone mineral density, Endometriosis, Gonadotropin-releasing hormone agonist, Raloxifene hydrochloride
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